CD226 Gene Summary [Human]
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CD226 |
| Official Name | CD226 molecule [Source:HGNC Symbol;Acc:HGNC:16961] |
| Ensembl ID | ENSG00000150637 |
| Bio databases IDs | |
| Aliases | CD226 molecule |
| Synonyms | CD226 antigen, CD226 molecule, DNAM-1, PTA1, TLiSA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD226 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoreceptor tyrosine tail-like domain
- extracellular domain
- signaling receptor activity
- protein kinase binding
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- integrin binding
- Immunoglobulin like
- protein binding
- identical protein binding
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the CD226 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- primary sclerosing cholangitis
- insulin-dependent diabetes mellitus
- hypothyroidism
- multiple sclerosis
- autoimmune thyroid disease
- idiopathic scoliosis
- plasma cell myeloma
- ulcerative colitis
- widespread chronic pain
role in cell
- cell death
- morphology
- apoptosis
- phosphorylation in
- expression in
- proliferation
- activation in
- production in
- migration
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD226 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell recognition
- cell adhesion
- positive regulation of immunoglobulin mediated immune response
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- positive regulation of Fc receptor mediated stimulatory signaling pathway
- positive regulation of natural killer cell mediated cytotoxicity
- positive regulation of T cell receptor signaling pathway
- positive regulation of interferon-gamma production
- positive regulation of mast cell activation
- cytokine production
- positive regulation of natural killer cell cytokine production
Cellular Component
Where in the cell the gene product is active
- membrane raft
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- cell adhesion molecule binding
- integrin binding