ITGAL Gene Summary [Human]
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ITGAL |
| Official Name | integrin subunit alpha L [Source:HGNC Symbol;Acc:HGNC:6148] |
| Ensembl ID | ENSG00000005844 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha L, antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide |
| Synonyms | CD11A, INTEGRIN alpha-L, integrin subunit alpha L, integrin subunit α L, INTEGRIN α-L, LFA-1, LFA-1A, LFA-1 α l, Ly-15, Ly-21, (p180) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITGAL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha cytoplasmic region
- extracellular domain
- idas domain
- von Willebrand factor (vWF) type A domain
- cell adhesion molecule binding
- inhibitory domain
- ICAM-3 receptor
- linker domain
- von Willebrand factor type A domain
- inserted domain
- protein binding
- alpha1 domain
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- binding protein
- cytoplasmic domain
- vWFA
- transmembrane domain
- FG-GAP repeat
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the ITGAL gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Tec Kinase Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- metabolic syndrome X
- coronary artery disease
- hyperplasia
- experimental autoimmune encephalomyelitis
- plaque psoriasis
- psoriasis
- dry eye
- Alzheimer disease
- keratoconjunctivitis sicca
role in cell
- phosphorylation in
- expression in
- activation in
- cellular infiltration by
- clustering
- clustering in
- proliferation
- binding in
- cell death
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- focal complexes
- intercellular junctions
- immunological synapses
- specific granule membrane
- plasma membrane extracellular face
- membrane rafts
- cell membrane leading edge
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITGAL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- memory T cell extravasation
- signal transduction
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- heterophilic cell-cell adhesion
- cell adhesion
- receptor clustering
- leukocyte cell-cell adhesion
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- inflammatory response
- phagocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- external side of plasma membrane
- alphaL-beta2 integrin complex
- integrin complex
- plasma membrane
- specific granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- cell adhesion molecule binding
- integrin binding
- ICAM-3 receptor activity