NECTIN2 Gene Summary [Human]
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NECTIN2 |
| Official Name | nectin cell adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:9707] |
| Ensembl ID | ENSG00000130202 |
| Bio databases IDs | |
| Aliases | nectin cell adhesion molecule 2 |
| Synonyms | CD112, HVEB, MPH, nectin cell adhesion molecule 2, PRR2, Pvr, PVRL2, PVRR2, Pvs |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NECTIN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- protein binding
- identical protein binding
- afadin binding domain
- cytoplasmic domain
- Immunoglobulin like
- protein homodimerization
- immunoglobulin-like protein domain
- receptor agonist activity
- transmembrane receptor
- Immunoglobulin V-set domain
- coreceptor
Pathways
Biological processes and signaling networks where the NECTIN2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- metabolic syndrome X
- Alzheimer disease
- breast cancer
- coronary artery disease
- teratozoospermia
- non-insulin-dependent diabetes mellitus
- frontotemporal dementia
- psychosis
- Parkinson disease
role in cell
- quantity
- penetration
- disruption
- aggregation
- activation
- differentiation
- cytolysis
- cell-cell adhesion
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- intercellular junctions
- cell-cell contacts
- intercalated disks
- anchoring junction
- junctional complexes
- zonula adherens
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NECTIN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- adhesion to host
- susceptibility to T cell mediated cytotoxicity
- cytoskeleton organization
- spermatid development
- sperm mitochondrion organization
- spermatid nucleus differentiation
- fertilization
- homophilic cell adhesion
- positive regulation of immunoglobulin mediated immune response
- virion attachment, binding of host cell surface coreceptor
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- positive regulation of natural killer cell mediated cytotoxicity
- acrosome assembly
- positive regulation of T cell receptor signaling pathway
- establishment of mitochondrion localization
- susceptibility to natural killer cell mediated cytotoxicity
- regulation of viral entry into host cell
- viral envelope fusion with host membrane
- positive regulation of mast cell activation
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- extracellular vesicular exosome
- cell-cell junction
- focal adhesion
- zonula adherens
- membrane
- apical junction complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- identical protein binding
- protein binding
- protein homodimerization activity
- cell adhesion molecule binding
- viral receptor activity