PVR Gene Summary [Human]
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | PVR |
| Official Name | PVR cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:9705] |
| Ensembl ID | ENSG00000073008 |
| Bio databases IDs | |
| Aliases | PVR cell adhesion molecule, nectin-like 5 |
| Synonyms | CD155, D7ERTD458E, HVED, NECL5, NECTIN 2 alpha, NECTIN 2 α, Pe4, PVR cell adhesion molecule, PVS, Taa1, TAGE4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PVR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- signaling receptor activity
- viral receptor
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- ectodomain
- protein binding
- cytoplasmic domain
- Immunoglobulin like
- dynein light chain binding
- receptor agonist activity
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the PVR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- Alzheimer disease
- colorectal carcinoma
- colorectal carcinomagenesis
- HER2 negative hormone receptor negative breast cancer
- infection by human poliovirus 1 Mahoney
- infection by human poliovirus 1
role in cell
- quantity
- proliferation
- growth
- phosphorylation in
- expression in
- degranulation
- migration
- production in
- density
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PVR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- susceptibility to natural killer cell mediated cytotoxicity
- susceptibility to T cell mediated cytotoxicity
- heterophilic cell-cell adhesion
- homophilic cell adhesion
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- adherens junction
- focal adhesion
- cytoplasm
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- cell adhesion molecule binding
- signaling receptor activity
- viral receptor activity