Vps45 Gene Summary [Mouse]
Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Located in Golgi membrane and endosome membrane. Human ortholog(s) of this gene implicated in severe congenital neutropenia 5. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps45 |
| Official Name | vacuolar protein sorting 45 [Source:MGI Symbol;Acc:MGI:891965] |
| Ensembl ID | ENSMUSG00000015747 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 45 |
| Synonyms | H1, H1VPS45, mVps45, SCN5, vacuolar protein sorting 45, vacuolar protein sorting 45 homolog, VPS45A, VPS45B, VPS54A, VSP45, VSP45A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Sec1 family
- transporter
Pathways
Biological processes and signaling networks where the Vps45 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- cellular membrane
- vesicles
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- endosomal membrane
- synaptic vesicles
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- membrane
- endosome membrane
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding