Csf3r Gene Summary [Mouse]
Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within neutrophil chemotaxis and regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including aorta-gonad-mesonephros; bone marrow; early conceptus; gut; and male reproductive gland or organ. Used to study hereditary neutrophilia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hereditary neutrophilia; and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csf3r |
| Official Name | colony stimulating factor 3 receptor (granulocyte) [Source:MGI Symbol;Acc:MGI:1339755] |
| Ensembl ID | ENSMUSG00000028859 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 3 receptor (granulocyte) |
| Synonyms | CD114, colony stimulating factor 3 receptor, Csfgr, G-CSF-R, G-CSF Receptor, G-CSF-R α, SCN7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csf3r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ig-like C2-type domain
- extracellular domain
- Box motif
- signaling receptor activity
- cytokine binding
- protein binding
- Fibronectin type 3 domain
- phosphotyrosine motif
- WSXWS motif
- dileucine internalization motif
- serine-rich region
- cytoplasmic domain
- FN3
- ligand-binding domain
- transmembrane domain
- intracellular domain
- membrane-proximal domain
- transmembrane receptor
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Csf3r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Diamond-Blackfan anemia
- rheumatoid arthritis
- Stevens-Johnson syndrome
- lymphoma
- cancer
- leukemia
- epithelial neoplasia
- epithelial cancer
- refractory multiple myeloma
- breast cancer
role in cell
- phosphorylation in
- apoptosis
- migration
- growth
- proliferation
- survival
- activation in
- expression in
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cellular membrane
- lysosome
- Golgi Apparatus
- lysosome membrane
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csf3r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cytokine-mediated signaling pathway
- neutrophil chemotaxis
- cell adhesion
- defense response
- regulation of myeloid cell differentiation
- amelogenesis
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- extracellular region
- endocytic vesicle membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- granulocyte colony-stimulating factor binding
- signaling receptor activity
- cytokine receptor activity
- cytokine binding