Stx16 Gene Summary [Mouse]

Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in several processes, including endosomal transport; vesicle docking; and vesicle fusion. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; connective tissue; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type 1B. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Stx16
Official Name
syntaxin 16 [Source:MGI Symbol;Acc:MGI:1923396]
Ensembl ID
ENSMUSG00000027522
Bio databases IDs NCBI: 228960 Ensembl: ENSMUSG00000027522
Aliases syntaxin 16
Synonyms 4930401D03, 5430410K23Rik, 6330500A18RIK, LOC679159, SYN-16, Syntaxin 16
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SNAP receptor
  • Helical region found in SNAREs
  • protein binding
  • SNARE motif
  • transporter
  • syntaxin binding

Pathways

Biological processes and signaling networks where the Stx16 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • nonalcoholic fatty liver disease
  • pseudohypoparathyroidism type 1B
regulated by
regulates
role in cell
  • accumulation in
  • formation in
  • formation
  • accumulation
  • transport in
  • cytokinesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Golgi-endosome fractions
  • synaptic vesicle membrane
  • intracellular membrane-bounded organelle
  • intracellular space
  • perinuclear region
  • cellular membrane
  • vesicles
  • Golgi Apparatus
  • Endoplasmic Reticulum
  • midbody
  • cytosol
  • Golgi membrane
  • trans Golgi network
  • growth cone
  • early endosomes
  • Golgi cisternae

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx16 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • vesicle fusion
  • vesicle docking
  • intracellular protein transport
  • retrograde transport, endosome to Golgi
  • endocytic recycling

Cellular Component

Where in the cell the gene product is active
  • Golgi membrane
  • Golgi apparatus
  • trans-Golgi network
  • perinuclear region of cytoplasm
  • focal adhesion
  • cytoplasm
  • intracellular membrane-bounded organelle
  • SNARE complex
  • cytosol
  • endomembrane system
  • synaptic vesicle membrane
  • Golgi cisterna
  • trans-Golgi network membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • syntaxin binding
  • SNAP receptor activity
  • SNARE binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.