Clcn2 Gene Summary [Mouse]
Enables voltage-gated chloride channel activity. Involved in chloride transport; regulation of resting membrane potential; and stabilization of membrane potential. Acts upstream of or within acinar cell differentiation; cell differentiation involved in salivary gland development; and retina development in camera-type eye. Located in astrocyte end-foot; basolateral plasma membrane; and myelin sheath. Is expressed in several structures, including central nervous system; gonad; hindlimb phalanx; notochord; and visual system. Used to study leukodystrophy and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clcn2 |
| Official Name | chloride channel, voltage-sensitive 2 [Source:MGI Symbol;Acc:MGI:105061] |
| Ensembl ID | ENSMUSG00000022843 |
| Bio databases IDs | |
| Aliases | chloride channel, voltage-sensitive 2 |
| Synonyms | chloride channel, voltage-sensitive 2, chloride voltage-gated channel 2, CIC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, FHA2, FHII, HALD2, LKPAT, LOC100912455, LOC108348101, nmf240 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- CBS_pair_SF
- volume-sensitive anion channel
- Voltage gated chloride channel
- chloride channel
- voltage-dependent ion-selective channel
- chloride channel regulator
- protein binding
- voltage-gated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to idiopathic generalized epilepsy type 11
- leukoencephalopathy with ataxia
- familial hyperaldosteronism type II
- azoospermia
- juvenile myoclonic epilepsy
- irritable bowel syndrome
- chronic idiopathic constipation
- childhood absence epilepsy
- hyperplasia
- leukodystrophy
regulates
- hormone
- renin
- chloride
- aldosterone
role in cell
- cell death
- apoptosis
- proliferation
- formation
- transmembrane potential
- differentiation
- morphology
- abnormal morphology
- function
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- axon component
- perinuclear region
- cellular membrane
- actin cytoskeleton
- basolateral membrane
- dendritic spines
- myelin sheath
- perikaryon
- dendrites
- astrocyte projections
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clcn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acinar cell differentiation
- phagocytosis, engulfment
- retina development in camera-type eye
- chloride transport
- lung development
- regulation of aldosterone biosynthetic process
- cell differentiation involved in salivary gland development
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite
- myelin sheath
- perikaryon
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated chloride channel activity