Bpifb1 Gene Summary [Mouse]
Predicted to enable lipid binding activity. Predicted to be involved in innate immune response in mucosa and negative regulation of toll-like receptor 4 signaling pathway. Predicted to be located in extracellular region. Is expressed in alimentary system; male reproductive gland or organ; primitive streak; respiratory system; and thymus. Orthologous to human BPIFB1 (BPI fold containing family B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bpifb1 |
| Official Name | BPI fold containing family B, member 1 [Source:MGI Symbol;Acc:MGI:2137431] |
| Ensembl ID | ENSMUSG00000027485 |
| Bio databases IDs | |
| Aliases | BPI fold containing family B, member 1 |
| Synonyms | BPI fold containing family B member 1, BPI fold containing family B, member 1, C20orf114, LPLUNC1, RGD1563047 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bpifb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BPI
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- neoplasia
- primary pulmonary hypertension
- laser induced choroidal neovascularization
- breast carcinoma
role in cell
- apoptosis
- expression in
- phosphorylation in
- colony formation
- proliferation
- production in
- binding in
- degradation in
- ubiquitination in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bpifb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response in mucosa
- negative regulation of toll-like receptor 4 signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- lipid binding