Toe1 Gene Summary [Mouse]
Predicted to enable poly(A)-specific ribonuclease activity and snRNA binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in Cajal body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Toe1 |
| Official Name | target of EGR1, member 1 (nuclear) [Source:MGI Symbol;Acc:MGI:1915526] |
| Ensembl ID | ENSMUSG00000028688 |
| Bio databases IDs | |
| Aliases | target of EGR1, member 1 (nuclear) |
| Synonyms | 4930584N22RIK, 4933424D16Rik, CAF1Z, hCaf1z, PCH7, target of EGR1, exonuclease, target of EGR1, member 1 (nuclear) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Toe1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- snRNA binding
- poly(A)-specific ribonuclease
- CAF1 family ribonuclease
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear speckles
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Toe1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- nuclear speck
- Cajal body
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- 3'-5'-exoribonuclease activity
- protein binding
- metal ion binding
- snRNA binding