Psmd2 Gene Summary [Mouse]
Predicted to enable enzyme regulator activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including central nervous system and retina. Orthologous to human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmd2 |
| Official Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [Source:MGI Symbol;Acc:MGI:1096584] |
| Ensembl ID | ENSMUSG00000006998 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
| Synonyms | 9430095H01Rik, P97, proteasome 26S subunit ubiquitin receptor, non-ATPase 2, proteasome (prosome, macropain) 26S subunit, non-ATPase, 2, RPN1, S2, TEG-190, Tex190, TRAP2, TUMOR NECROSIS FACTOR type 1 receptor-ASSOCIATED protein 2, tumour NECROSIS FACTOR type 1 receptor-ASSOCIATED protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
- RPN1 N-terminal domain
- KEKE domain
- coiled-coil domain
- protein binding
- Proteasome/cyclosome repeat
Pathways
Biological processes and signaling networks where the Psmd2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- plasma cell myeloma
- progressive multiple myeloma
- lymphoplasmacytic lymphoma
- relapsed multiple myeloma
- immune thrombocytopenia
- refractory multiple myeloma
- systemic light chain amyloidosis
- B-cell acute lymphoblastic lymphoma
- idiopathic thrombocytopenic purpura
role in cell
- proliferation
- cell death
- degradation in
- replication in
- growth
- fragmentation
- fragmentation in
- formation
- activation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ciliary transition zone
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- basal bodies
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- clastosomes
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein catabolic process
Cellular Component
Where in the cell the gene product is active
- proteasome regulatory particle, base subcomplex
- proteasome complex
- proteasome accessory complex
- extracellular region
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- proteasome regulatory particle
- membrane
- cytosol
- secretory granule lumen
- proteasome storage granule
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme regulator activity