Dll4 Gene Summary [Mouse]
Enables Notch binding activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway; angiogenesis; and negative regulation of blood vessel endothelial cell migration. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and retina. Used to study Adams-Oliver syndrome. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dll4 |
| Official Name | delta like canonical Notch ligand 4 [Source:MGI Symbol;Acc:MGI:1859388] |
| Ensembl ID | ENSMUSG00000027314 |
| Bio databases IDs | |
| Aliases | delta like canonical Notch ligand 4 |
| Synonyms | AOS6, Delta4, delta like canonical Notch ligand 4, hdelta2, Notch Ligand Delta-like 4, Notch Ligand δ-like 4, δ like canonical Notch ligand 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dll4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- N terminus of Notch ligand C2-like domain
- Human growth factor-like EGF
- intracellular domain
- receptor agonist activity
- protein binding
- EGF repeat
- notch binding
- Delta serrate ligand
- EGF_CA
Pathways
Biological processes and signaling networks where the Dll4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- acute myeloid leukemia
- Adams-Oliver syndrome type 6
- atresia
- airway hyperresponsiveness
- metastatic extrahepatic cholangiocarcinoma
- carcinoma of ampulla of Vater
- extrahepatic cholangiocarcinoma
- tumorigenesis
role in cell
- activation
- quantity
- migration
- apoptosis
- activation in
- binding in
- proliferation
- expression in
- upregulation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dll4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neural retina development
- negative regulation of cell proliferation
- negative regulation of Notch signaling pathway
- positive regulation of Notch signaling pathway
- negative regulation of cell migration involved in sprouting angiogenesis
- negative regulation of transcription from RNA polymerase II promoter
- cardiac ventricle morphogenesis
- patterning of blood vessels
- angiogenesis
- cardiac atrium morphogenesis
- positive regulation of neural precursor cell proliferation
- dorsal aorta morphogenesis
- negative regulation of endothelial cell migration
- aortic valve morphogenesis
- signal transduction
- cellular response to fibroblast growth factor stimulus
- visual perception
- ventricular trabecula myocardium morphogenesis
- pericardium morphogenesis
- ventral spinal cord interneuron fate commitment
- T cell differentiation
- negative regulation of gene expression
- blood vessel remodeling
- Notch signaling pathway
- blood vessel lumenization
- positive regulation of gene expression
- cellular response to vascular endothelial growth factor stimulus
- regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- Notch binding
- receptor agonist activity