Angpt1 Gene Summary [Mouse]
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | Angpt1 |
| Official Name | angiopoietin 1 [Source:MGI Symbol;Acc:MGI:108448] |
| Ensembl ID | ENSMUSG00000022309 |
| Bio databases IDs | |
| Aliases | angiopoietin 1 |
| Synonyms | 1110046O21Rik, AGP1, AGPT, AGPT-1, ANG1, angiopoietin 1, HAE5, KIAA0003 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Angpt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ciliary protein causing Leber congenital amaurosis disease
- fibrinogen-like domain
- receptor tyrosine kinase binding
- receptor agonist activity
- linker domain
- coiled-coil domain
- protein binding
- receptor binding
- vascular endothelial growth factor receptor binding
- FReD
- identical protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Angpt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- ovarian cancer
- gastrointestinal stromal tumor
- Kawasaki disease
- gastrointestinal stromal neoplasia
- glaucoma
- refractive error
- open-angle glaucoma
- obesity
role in cell
- survival
- migration
- expression in
- tubulation
- phosphorylation in
- proliferation
- activation in
- apoptosis
- production in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix fraction
- Cytoplasm
- perinuclear region
- Plasma Membrane
- extracellular matrix
- membrane rafts
- microvilli
- perivascular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Angpt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of transmembrane receptor protein tyrosine kinase activity
- protein localization at cell surface
- positive chemotaxis
- hemopoiesis
- sprouting angiogenesis
- regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of cell adhesion
- negative regulation of neuron apoptotic process
- angiogenesis
- in utero embryonic development
- positive regulation of protein ubiquitination
- negative regulation of cytokine production involved in immune response
- negative regulation of endothelial cell apoptotic process
- positive regulation of endothelial cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- neuron apoptotic process
- positive regulation of peptidyl-serine phosphorylation
- negative regulation of protein import into nucleus
- positive regulation of receptor internalization
- negative regulation of cell adhesion
- regulation of tumor necrosis factor production
- negative regulation of vascular permeability
- positive regulation of blood vessel endothelial cell migration
- negative regulation of apoptotic process
- positive regulation of gene expression
- negative regulation of protein phosphorylation
- Tie receptor signaling pathway
- glomerulus vasculature development
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- regulation of endothelial cell proliferation
- heparin biosynthetic process
- cell-substrate adhesion
- regulation of macrophage migration inhibitory factor signaling pathway
- regulation of satellite cell proliferation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- microvillus
- membrane raft
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- receptor tyrosine kinase binding