Synj2bp Gene Summary [Mouse]
Enables type II activin receptor binding activity. Involved in positive regulation of protein localization to cell surface; positive regulation of receptor internalization; and regulation of activin receptor signaling pathway. Acts upstream of or within Rho protein signal transduction; protein targeting; and regulation of endocytosis. Located in cell surface. Is expressed in several structures, including blood vessel; extraembryonic component; genitourinary system; neural tube; and retina. Orthologous to human SYNJ2BP (synaptojanin 2 binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Synj2bp |
| Official Name | synaptojanin 2 binding protein [Source:MGI Symbol;Acc:MGI:1344347] |
| Ensembl ID | ENSMUSG00000090935 |
| Bio databases IDs | |
| Aliases | synaptojanin 2 binding protein |
| Synonyms | AA409442, ActRIP4, ARIP2, D12Wsu118e, OMP25, synaptojanin 2 binding protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Synj2bp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- receptor binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- prostatic carcinoma
role in cell
- migration
- proliferation
- migration by
- endocytosis by
- organization
- clustering
- distribution in
- distribution
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- cell surface
- Mitochondria
- mitochondrial outer membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Synj2bp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- protein targeting
- regulation of Notch signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of endothelial cell proliferation
- regulation of endocytosis
- Rho protein signal transduction
- negative regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding