Mib1 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including Notch signaling pathway; chordate embryonic development; and circulatory system development. Located in cytoplasmic vesicle. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mib1 |
| Official Name | mindbomb E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:2443157] |
| Ensembl ID | ENSMUSG00000024294 |
| Bio databases IDs | |
| Aliases | mindbomb E3 ubiquitin protein ligase 1 |
| Synonyms | DIP-1, E430019M12Rik, LOC105376866, LVNC7, MIB, MIB E3 ubiquitin protein ligase 1, mindbomb, ZZANK2, ZZZ6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mib1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- Mib_herc2
- Ankyrin repeats (many copies)
- Mind bomb SH3 repeat domain
- Ankyrin repeats (3 copies)
- enzyme
- protein binding
- Ankyrin repeat
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- ankyrin repeats
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dilated cardiomyopathy
- splenomegaly
- growth failure
- failure of heart looping
- left ventricular noncompaction type 7
- anemia
- granulocytosis
- edema
- chorioallantoic membrane fusion failure
role in cell
- cell death
- expression in
- apoptosis
- accumulation
- differentiation
- formation
- outgrowth
- cohesion
- morphology
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- pericentriolar matrix
- centriolar satellite
- Plasma Membrane
- centrosome
- centriole
- cytosol
- synaptic vesicles
- early endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mib1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- positive regulation of endocytosis
- negative regulation of neuron differentiation
- endocytosis
- ubiquitin-dependent protein catabolic process
- neural tube formation
- Notch signaling pathway
- blood vessel development
- somitogenesis
- in utero embryonic development
- heart looping
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- centriolar satellite
- cytosol
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding