Hdac7 Gene Summary [Mouse]
Enables chromatin binding activity; histone deacetylase activity; and transcription corepressor activity. Acts upstream of or within cell-cell junction assembly; negative regulation of transcription by RNA polymerase II; and vasculogenesis. Is active in nucleus. Is expressed in several structures, including adrenal gland; cerebral cortex; heart; and sensory organ. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdac7 |
| Official Name | histone deacetylase 7 [Source:MGI Symbol;Acc:MGI:1891835] |
| Ensembl ID | ENSMUSG00000022475 |
| Bio databases IDs | |
| Aliases | histone deacetylase 7 |
| Synonyms | 5830434K02Rik, HD7, HD7A, HDAC7A, HDAC-D, histone deacetylase 7, mFLJ00062 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hdac7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- SUMO transferase activity
- protein kinase binding
- catalytic domain
- transcription co-repressor
- deacetylase motif
- protein kinase C binding
- chromatin binding
- transcription factor binding
- protein binding
- Arginase-like and histone-like hydrolases
- protein deacetylase activity
- histone deacetylase
Pathways
Biological processes and signaling networks where the Hdac7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Nur77 Signaling in T Lymphocytes
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- non-small cell lung cancer
- neoplasia
- diffuse large B-cell lymphoma
- ulcerative colitis
- systemic lupus erythematosus
- hyperglycemia
- primary sclerosing cholangitis
- multiple sclerosis
- B-cell non-Hodgkin disease
role in cell
- expression in
- organization
- phosphorylation in
- activation
- differentiation
- proliferation
- migration
- formation
- ubiquitination in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- nuclear foci
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hdac7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of mRNA processing
- negative regulation of interleukin-2 production
- cell-cell junction assembly
- protein sumoylation
- protein deacetylation
- vasculogenesis
- positive regulation of cell migration involved in sprouting angiogenesis
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein kinase binding
- protein binding
- histone deacetylase activity
- metal ion binding
- transcription corepressor activity
- chromatin binding
- protein deacetylase activity
- SUMO ligase activity
- 14-3-3 protein binding