Ncoa6 Gene Summary [Mouse]
Enables several functions, including chromatin binding activity; histone methyltransferase binding activity; and transcription coactivator activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncoa6 |
| Official Name | nuclear receptor coactivator 6 [Source:MGI Symbol;Acc:MGI:1929915] |
| Ensembl ID | ENSMUSG00000038369 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 6 |
| Synonyms | AIB3, ASC-2, Erap140, mKIAA0181, Ncoa7, NRC, nuclear receptor coactivator 6, PRIP, RAP250, TRBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncoa6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AD2 domain
- Ser-Thr-Leu rich region
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- nuclear receptor domain
- transcription co-activator
- retinoic acid receptor binding
- protein binding activity, bridging
- vitamin D receptor binding
- IXXIM motif
- enzyme binding
- chromatin binding
- protein domain specific binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- identical protein binding
- androgen receptor binding domain
- autonomous transactivation domain
- peroxisome proliferator activated receptor binding
- Putative nucleic acid-binding region
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the Ncoa6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- venous thromboembolism
- melanoma
- melanoma cancer
- coronary artery disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- non-melanoma skin cancer
phenotypes
- abnormal retina morphology
- decreased total body fat amount
- increased thigmotaxis
- preweaning lethality incomplete penetrance
- abnormal bile salt homeostasis
- abnormal blood vessel morphology
- abnormal brain development
- abnormal cell physiology
- abnormal digit morphology
- abnormal embryonic hematopoiesis
- abnormal epicardium morphology
- abnormal eye pigmentation
- abnormal feces composition
- abnormal fetal cardiomyocyte morphology
- abnormal fetal cardiomyocyte proliferation
- abnormal heart development
- abnormal heart morphology
- abnormal heart ventricle morphology
- abnormal hepatocyte morphology
- abnormal hypothalamus morphology
- abnormal lens morphology
- abnormal lipid homeostasis
- abnormal liver bud morphology
- abnormal liver development
- abnormal liver morphology
- abnormal myocardium layer morphology
- abnormal palatal shelf fusion at midline
- abnormal placenta development
- abnormal placenta morphology
- abnormal placenta vasculature
- abnormal placental labyrinth vasculature morphology
- abnormal spongiotrophoblast layer morphology
- abnormal syncytiotrophoblast morphology
- abnormal triglyceride level
- abnormal trophoblast giant cell morphology
- abnormal trophoblast layer morphology
- abnormal vascular development
- abnormal vitelline vasculature morphology
- absent olfactory bulb
- absent placental labyrinth
- cataract
- decreased birth body size
- decreased birth weight
- decreased embryo size
- decreased erythroid progenitor cell number
- decreased fetal cardiomyocyte proliferation
- decreased fibroblast proliferation
- decreased hair follicle number
- decreased hepatocyte number
- decreased litter size
- decreased neuron number
- decreased spongiotrophoblast cell number
- decreased spongiotrophoblast size
- delayed brain development
- delayed wound healing
- dilated third ventricle
- dilated vasculature
- disorganized myocardium
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- embryonic lethality complete penetrance
- female infertility
- heart hypoplasia
- impaired placental function
- impaired wound healing
- increased circulating cholesterol level
- increased fibroblast apoptosis
- increased hepatocyte apoptosis
- increased liver weight
- increased sebaceous gland number
- increased trophoblast giant cell number
- lethality throughout fetal growth and development complete penetrance
- neonatal lethality incomplete penetrance
- oligodactyly
- pallor
- pericardial effusion
- prenatal lethality incomplete penetrance
- reduced female fertility
- reduced male fertility
- small lens
- small liver
- small thalamus
- thick epidermis
- thin myocardium
- thin myocardium compact layer
- thin ventricular wall
- trabecula carnea hypoplasia
role in cell
- activation in
- expression in
- quantity
- proliferation
- apoptosis
- differentiation
- growth
- migration
- formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncoa6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- positive regulation of transcription, DNA-dependent
- myeloid cell differentiation
- transcription initiation, DNA-dependent
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- histone methyltransferase complex
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- estrogen receptor binding
- chromatin binding
- retinoid X receptor binding
- thyroid hormone receptor binding
- enzyme binding