NCOA6 Gene Summary [Human]
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Details
| Type | Processed Transcript |
| Official Symbol | NCOA6 |
| Official Name | nuclear receptor coactivator 6 [Source:HGNC Symbol;Acc:HGNC:15936] |
| Ensembl ID | ENSG00000198646 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 6, nuclear receptor coactivator RAP250, activating signal cointegrator-2, peroxisome proliferator-activated receptor interacting protein |
| Synonyms | AIB3, ASC-2, Erap140, mKIAA0181, Ncoa7, NRC, nuclear receptor coactivator 6, PRIP, RAP250, TRBP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCOA6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AD2 domain
- Ser-Thr-Leu rich region
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- nuclear receptor domain
- transcription co-activator
- retinoic acid receptor binding
- protein binding activity, bridging
- vitamin D receptor binding
- IXXIM motif
- enzyme binding
- chromatin binding
- protein domain specific binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- identical protein binding
- androgen receptor binding domain
- autonomous transactivation domain
- peroxisome proliferator activated receptor binding
- Putative nucleic acid-binding region
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the NCOA6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- venous thromboembolism
- melanoma
- melanoma cancer
- coronary artery disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- non-melanoma skin cancer
role in cell
- activation in
- expression in
- quantity
- proliferation
- apoptosis
- differentiation
- growth
- migration
- formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCOA6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- positive regulation of transcription, DNA-dependent
- myeloid cell differentiation
- transcription initiation, DNA-dependent
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- histone methyltransferase complex
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- estrogen receptor binding
- chromatin binding
- retinoid X receptor binding
- thyroid hormone receptor binding
- enzyme binding