Psmb7 Gene Summary [Mouse]
Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in liver. Orthologous to human PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmb7 |
| Official Name | proteasome (prosome, macropain) subunit, beta type 7 [Source:MGI Symbol;Acc:MGI:107637] |
| Ensembl ID | ENSMUSG00000026750 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) subunit, beta type 7 |
| Synonyms | AU020723, Macropain chain Z, MC14, proteasome 20S subunit beta 7, proteasome 20S subunit β 7, proteasome (prosome, macropain) subunit, beta type 7, proteasome (prosome, macropain) subunit, β type 7, Proteasome subunit beta2c, Proteasome subunit b type 7, Proteasome subunit Z, Proteasome subunit β2c, PSB7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmb7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypothyroidism
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
regulates
role in cell
- survival
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- cilia
- Extracellular Space
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmb7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- proteasome core complex
- cytosol
- proteasome complex
- secretory granule lumen
- proteasome core complex, beta-subunit complex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- threonine-type endopeptidase activity