Igll1 Gene Summary [Mouse]
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in endoplasmic reticulum and extracellular region. Predicted to be part of IgG immunoglobulin complex. Is expressed in bone marrow; embryo; lesser omentum; liver; and yolk sac. Human ortholog(s) of this gene implicated in agammaglobulinemia 2. Orthologous to several human genes including IGLL5 (immunoglobulin lambda like polypeptide 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igll1 |
| Official Name | immunoglobulin lambda-like polypeptide 1 [Source:MGI Symbol;Acc:MGI:96529] |
| Ensembl ID | ENSMUSG00000075370 |
| Bio databases IDs | |
| Aliases | immunoglobulin lambda-like polypeptide 1 |
| Synonyms | 14.1, AGM2, CD179b, IGL1, IGL-5, Ig lambda chain 5, IGLJ14.1, IGLL, IGO, IG OMEGA, IGVPB, Ig λ chain 5, IG ω, immunoglobulin lambda-like polypeptide 1, immunoglobulin λ-like polypeptide 1, Lambda5, VPREB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta strand or sheet
- Immunoglobulin C1-set domain
- immunoglobulin domain
- tail domain
- protein binding
- unique protein domain
Pathways
Biological processes and signaling networks where the Igll1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- epithelial cancer
- agammaglobulinemia type 2
- hypoplasia
- agammaglobulinemia
- mucoepidermoid carcinoma
- polyglandular autoimmune syndrome type 1
- lepromatous leprosy
role in cell
- proliferation
- quantity
- abnormal morphology
- number
- differentiation
- development
- abnormal number
- maturation
- deposition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igll1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- immunoglobulin mediated immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- endoplasmic reticulum
- extracellular region
- IgG immunoglobulin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- antigen binding