Ms4a4a Gene Summary [Mouse]
Predicted to be located in endoplasmic reticulum and plasma membrane raft. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to several human genes including MS4A4A (membrane spanning 4-domains A4A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ms4a4a |
| Official Name | membrane-spanning 4-domains, subfamily A, member 4A [Source:MGI Symbol;Acc:MGI:3643932] |
| Ensembl ID | ENSMUSG00000101389 |
| Bio databases IDs | |
| Aliases | membrane-spanning 4-domains, subfamily A, member 4A |
| Synonyms | 4SPAN1, CD20-L1, EG666907, HDCME31P, LOC624461, membrane spanning 4-domains A4A, membrane-spanning 4-domains, subfamily A, member 4A, MS4A4, MS4A7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ms4a4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- CD20-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- nonobstructive azoospermia
- Alzheimer disease
- late-onset Alzheimer disease
- flu
- febrile seizure
- dermatomyositis
- hypertension
- ischemic stroke
- sepsis
role in cell
- phosphorylation in
- proliferation
- signaling in
- migration
- endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- early endosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ms4a4a gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding