Agpat2 Gene Summary [Mouse]
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in triglyceride biosynthetic process. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and urinary system. Used to study congenital generalized lipodystrophy type 1. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Agpat2 |
| Official Name | 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) [Source:MGI Symbol;Acc:MGI:1914762] |
| Ensembl ID | ENSMUSG00000026922 |
| Bio databases IDs | |
| Aliases | 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) |
| Synonyms | 1-acylglycerol-3-phosphate O-acyltransferase 2, 1-AGPAT 2, 2510002J07Rik, BSCL, BSCL1, LPAAB, LPAAT-beta, LPAAT-β, LPLAT2, lysophosphatidic acid acyltransferase beta, lysophosphatidic acid acyltransferase β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agpat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- Acyltransferase
Pathways
Biological processes and signaling networks where the Agpat2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial ovarian cancer
- ovarian cancer
- clear-cell ovarian carcinoma
- congenital generalized lipodystrophy type 1
- endometrioid cancer
- serous ovarian cancer
- endometrioid carcinoma
- clear cell ovarian cancer
- polydipsia
phenotypes
- abnormal abdominal fat pad morphology
- abnormal brown adipose tissue morphology
- abnormal dentin development
- abnormal fatty acid level
- abnormal gas homeostasis
- abnormal glucose homeostasis
- abnormal incisor morphology
- abnormal lipid homeostasis
- abnormal liver morphology
- abnormal phospholipid level
- abnormal small intestine morphology
- abnormal white fat cell morphology
- absent subcutaneous adipose tissue
- adipose tissue inflammation
- adipose tissue necrosis
- ameloblast degeneration
- decreased body size
- decreased body temperature
- decreased body weight
- decreased brown adipose tissue amount
- decreased circulating free fatty acid level
- decreased circulating leptin level
- decreased percent body fat/body weight
- decreased respiratory quotient
- decreased survivor rate
- decreased total body fat amount
- decreased white adipose tissue amount
- decreased white fat cell number
- decreased white fat cell size
- distended abdomen
- enlarged liver
- enlarged pancreatic islets
- femur fracture
- granulomatous inflammation
- hepatic steatosis
- hyperglycemia
- hypoactivity
- improved glucose tolerance
- increased carbon dioxide production
- increased circulating cholesterol level
- increased circulating glucose level
- increased circulating insulin level
- increased circulating triglyceride level
- increased fluid intake
- increased food intake
- increased kidney weight
- increased liver triglyceride level
- increased liver weight
- increased oxygen consumption
- increased pancreatic beta cell mass
- increased pancreatic beta cell number
- increased spleen weight
- insulin resistance
- lipodystrophy
- liver inflammation
- microvesicular hepatic steatosis
- pale liver
- polydipsia
- postnatal lethality incomplete penetrance
- premature death
- reduced enamel thickness
- rough coat
role in cell
- apoptosis
- expression in
- growth
- number
- formation in
- formation
- mass
- replication in
- incorporation in
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- membrane fraction
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- specific granule membrane
- endoplasmic reticulum membrane
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agpat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytokine-mediated signaling pathway
- epidermis development
- triglyceride biosynthetic process
- response to xenobiotic stimulus
- CDP-diacylglycerol biosynthetic process
- phospholipid metabolic process
- positive regulation of cytokine production
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity