Xpo5 Gene Summary [Mouse]
Enables nuclear export signal receptor activity and tRNA binding activity. Acts upstream of or within protein export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RISC complex and RNA nuclear export complex. Predicted to be active in cytoplasm and nucleus. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and head. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung carcinoma (multiple); multiple myeloma; and primary ovarian insufficiency. Orthologous to human XPO5 (exportin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xpo5 |
| Official Name | exportin 5 [Source:MGI Symbol;Acc:MGI:1913789] |
| Ensembl ID | ENSMUSG00000067150 |
| Bio databases IDs | |
| Aliases | exportin 5 |
| Synonyms | 2410004H11Rik, 2700038C24Rik, EXP5, Exportin 5, KIAA1291, mKIAA1291, RanBp21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xpo5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- mRNA binding
- Exportin 1-like protein
- ribonucleoprotein binding
- enzyme binding
- protein binding
- Importin-beta N-terminal domain
- nuclear export signal receptor
- Exportin-5 family
- RNA binding
Pathways
Biological processes and signaling networks where the Xpo5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Wilms tumor
- Wilms tumorigenesis
- lung adenocarcinoma formation
- esophageal cancer
- abdominal cancer
- mixed neoplasia
- renal cancer
- renal neoplasia
- retroperitoneal cancer
role in cell
- accumulation in
- expression in
- sphere formation
- recognition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xpo5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA export from nucleus
- pre-miRNA export from nucleus
- protein export from nucleus
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- RNA-induced silencing complex
- RNA nuclear export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- small GTPase binding
- mRNA binding
- pre-miRNA binding
- tRNA binding
- nuclear export signal receptor activity