NOX1
NOX1 Gene Summary
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | NOX1 |
| Official Name | NADPH oxidase 1 [Source:HGNC Symbol;Acc:HGNC:7889] |
| Ensembl ID | ENSG00000007952 |
| Bio databases IDs | |
| Aliases | NADPH oxidase 1, mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating), NADPH oxidase homolog-1 |
| Synonyms | GP91-2,MOX1,NADPHox,NADPH oxidase 1,NOH-1,NOH-1L,NOX1a,NOX1alpha |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- NADPH oxidase
- Cytochrome_b_N
- enzyme binding
- heme binding domain
- enzyme
- protein binding
- Oxidoreductase NAD-binding domain
- superoxide-generating NADPH oxidase
Pathways
Biological processes and signaling networks where the NOX1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RELA
- FBXW7
- setanaxib
- FZR1
- CYBA
- NOXA1
- KRAS
- PPP2R3B
- RAB34
- RHBDD1
disease
- neoplasia
- diabetes mellitus
- metastasis
- thermal hyperalgesia
- fibrosis
- nonalcoholic fatty liver disease
- mechanical hyperalgesia
- very early onset inflammatory bowel disease
regulated by
- hydrogen peroxide
- atorvastatin
- TNF
- tetradecanoylphorbol acetate
- SOAT1
- lipopolysaccharide
- hepatitis C virus subtype 1b
- SRC (family)
- NoxA1ds
- NOXO1
regulates
- nitric oxide
- superoxide
- CAT
- NOS2
- glutathione
- adenosine triphosphate
- reactive oxygen species
- RELA
- MMP9
- AKT
role in cell
- cell death
- expression in
- apoptosis
- growth
- phosphorylation in
- proliferation
- activation in
- formation
- quantity
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cellular membrane
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NOX1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of integrin biosynthetic process
- regulation of systemic arterial blood pressure by renin-angiotensin
- signal transduction
- positive regulation of cell proliferation
- induction of apoptosis by oxidative stress
- JNK cascade
- respiratory burst
- superoxide anion generation
- defense response
- regulation of blood pressure
- hydrogen peroxide metabolic process
- positive regulation of smooth muscle cell proliferation
- oxygen metabolic process
- inflammatory response
- angiogenesis
- positive regulation of JNK cascade
- NADP metabolic process
- extracellular matrix organization
- cellular response to hyperoxia
- cell migration
- positive regulation vascular endothelial growth factor production
CELLULAR COMPONENT
Where in the cell the gene product is active
- early endosome
- anchoring junction
- NADPH oxidase complex
- cell projection
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- NADP binding
- protein binding
- metal ion binding
- superoxide-generating NADPH oxidase activity
- small GTPase binding