ETV7 Gene Summary [Human]
The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | ETV7 |
| Official Name | ETS variant transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:18160] |
| Ensembl ID | ENSG00000010030 |
| Bio databases IDs | |
| Aliases | ETS variant transcription factor 7, TEL2 oncogene |
| Synonyms | ETS variant transcription factor 7, TEL-2, TEL2B, TELB, TREF |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ETV7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- SAM (Sterile alpha motif )
- Ets-domain
- pointed domain
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- pemphigus foliaceus
- systemic lupus erythematosus
- multiple sclerosis
role in cell
- binding in
- signaling in
- expression in
- apoptosis
- differentiation
- proliferation
- phosphorylation in
- growth
- migration
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ETV7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell differentiation
- transcription from RNA polymerase II promoter
- organ morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity