MAP4K5 Gene Summary [Human]
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | MAP4K5 |
| Official Name | mitogen-activated protein kinase kinase kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6867] |
| Ensembl ID | ENSG00000012983 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase kinase 5, germinal center kinase-related |
| Synonyms | 4432415E19Rik, GCKR, KHS, KHS1, MAPKKKK5, mitogen-activated protein kinase kinase kinase kinase 5, RGD1562028 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP4K5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- CNH domain
- ATP binding
- protein binding
- Protein kinase domain
- proline rich domain
- kinase
- germinal center kinase homology domain
- Serine/Threonine protein kinases, catalytic domain
- PEST domain
- Protein Kinases, catalytic domain
- C-terminal extension
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP4K5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- advanced lung squamous cell carcinoma
- advanced large cell lung carcinoma
- cancer
- advanced non-small cell lung cancer
- metastatic large cell lung carcinoma
- advanced non-small cell lung adenocarcinoma
- metastatic lung adenocarcinoma
- stage IV lung squamous cell carcinoma
- metastatic non-small cell lung cancer
- metastasis
role in cell
- phosphorylation in
- function
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP4K5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- MAP kinase kinase kinase kinase activity