TANK Gene Summary [Human]
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | TANK |
| Official Name | TRAF family member associated NFKB activator [Source:HGNC Symbol;Acc:HGNC:11562] |
| Ensembl ID | ENSG00000136560 |
| Bio databases IDs | |
| Aliases | TRAF family member associated NFKB activator |
| Synonyms | E430026L09Rik, I-TRAF, TRAF2, TRAF family member-associated Nf-kappa B activator, TRAF family member-associated NFKB activator, TRAF family member-associated Nf-κ B activator, TRAF-INTERACTING protein 1-TRAF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TANK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TBK1/IKKi-binding domain
- ubiquitin protein ligase binding
- TBD domain
- TRAF binding domain
- SUMO1 conjugation site
- ubiquitin-specific protease
- coiled-coil domain
- protein binding
- zinc finger domain
- IKK binding domain
- protease activator
Pathways
Biological processes and signaling networks where the TANK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- autoimmune glomerulonephritis
- glomerulonephritis
- hyperplasia
- inflammatory disorder
- pervasive developmental disorder
- COVID-19
- hypothyroidism
- cannabis dependence
- opioid-related disorder
role in cell
- activity
- proliferation
- cell death
- formation
- survival
- production in
- expression in
- phosphorylation in
- number
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TANK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of type I interferon production
- cellular response to interleukin-1
- cellular response to ionizing radiation
- defense response to virus
- cellular response to tumor necrosis factor
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- response to DNA damage stimulus
- positive regulation of ubiquitin-specific protease activity
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- ubiquitin protein ligase binding
- metal ion binding
- ubiquitin-specific protease activator activity
- binding, bridging