UBE2N Gene Summary [Human]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | UBE2N |
| Official Name | ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] |
| Ensembl ID | ENSG00000177889 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 N |
| Synonyms | 1500026J17Rik, BB101821, HEL-S-71, UBC1, UBC13, UbcH13, UBCHBEN, ubiquitin-conjugating enzyme E2N |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2N often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- catalytic domain
- ubiquitin-protein transferase activity
- UBCc_UEV
- ubiquitin binding
- enzyme
- protein binding
- enzyme regulator activity
- enzyme activator activity
Pathways
Biological processes and signaling networks where the UBE2N gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- metastasis
- psoriasis
- nonalcoholic fatty liver disease
role in cell
- apoptosis
- proliferation
- production in
- binding in
- migration
- activation in
- growth
- binding
- cell death
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE2N gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA double-strand break processing
- regulation of DNA repair
- double-strand break repair via homologous recombination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- postreplication repair
- proteasomal ubiquitin-dependent protein catabolic process
- protein K63-linked ubiquitination
- positive regulation of double-strand break repair
- T cell receptor signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- ubiquitin ligase complex
- UBC13-MMS2 complex
- cytoplasm
- ubiquitin conjugating enzyme complex
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- ubiquitin protein ligase binding
- protein binding
- RNA binding
- ubiquitin binding
- ubiquitin-protein ligase activator activity