SH2D2A Gene Summary [Human]
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | SH2D2A |
| Official Name | SH2 domain containing 2A [Source:HGNC Symbol;Acc:HGNC:10821] |
| Ensembl ID | ENSG00000027869 |
| Bio databases IDs | |
| Aliases | SH2 domain containing 2A, T lymphocyte specific adaptor protein, T cell specific adapter protein TSAd, T cell specific adpater protein TSAd |
| Synonyms | F2771, LAD, Ribp, Rlk-binding, SCAP, SH2 domain containing 2A, TSAD, VRAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SH2D2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein binding
- proline rich domain
- Sh3 domain binding motif
Pathways
Biological processes and signaling networks where the SH2D2A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- breast cancer
- juvenile rheumatoid arthritis
- hypothyroidism
- colorectal cancer
- insulin-dependent diabetes mellitus
- soft tissue sarcoma
- soft tissue sarcoma cancer
- autoimmune thyroid disease
- glomerulonephritis
role in cell
- expression in
- formation
- activation in
- production in
- proliferation
- migration
- cell death
- phosphorylation in
- accumulation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- microtubule organizing centers
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SH2D2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- signal transduction
- T cell proliferation
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding