Sh2d2a Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within T cell proliferation. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis and multiple sclerosis. Orthologous to human SH2D2A (SH2 domain containing 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh2d2a |
| Official Name | SH2 domain containing 2A [Source:MGI Symbol;Acc:MGI:1351596] |
| Ensembl ID | ENSMUSG00000028071 |
| Bio databases IDs | |
| Aliases | SH2 domain containing 2A |
| Synonyms | F2771, LAD, Ribp, Rlk-binding, SCAP, SH2 domain containing 2A, TSAD, VRAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh2d2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein binding
- proline rich domain
- Sh3 domain binding motif
Pathways
Biological processes and signaling networks where the Sh2d2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- breast cancer
- juvenile rheumatoid arthritis
- hypothyroidism
- colorectal cancer
- insulin-dependent diabetes mellitus
- soft tissue sarcoma
- soft tissue sarcoma cancer
- autoimmune thyroid disease
- glomerulonephritis
role in cell
- expression in
- formation
- activation in
- production in
- proliferation
- migration
- cell death
- phosphorylation in
- accumulation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- microtubule organizing centers
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh2d2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- signal transduction
- T cell proliferation
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding