ARID4A Gene Summary [Human]
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARID4A |
| Official Name | AT-rich interaction domain 4A [Source:HGNC Symbol;Acc:HGNC:9885] |
| Ensembl ID | ENSG00000032219 |
| Bio databases IDs | |
| Aliases | AT-rich interaction domain 4A |
| Synonyms | A630009N03, A630067N03Rik, AT-rich interaction domain 4A, RB-binding protein 1, RBBP-1, RBP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARID4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- R2 domain
- transcription regulator
- transcription repression domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- r1 domain
- RBB1NT (NUC162) domain
- Tudor domain superfamily
- ARID/BRIGHT DNA binding domain
- malignant brain tumor (MBT) repeat
- DNA binding
- ARID/BRIGHT DNA binding domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cancer
- leukemia
- coronary artery disease
- acute myeloid leukemia
- thrombocytopenia
- anemia
- hemophagocytosis
- agenesis
- metabolic syndrome X
role in cell
- expression in
- number
- proliferation
- organization
- differentiation
- growth
- abnormal morphology
- quantity
- development
- trimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARID4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- spermatogenesis
- transcription from RNA polymerase II promoter
- erythrocyte development
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
- genetic imprinting
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- plasma membrane
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription regulatory region sequence-specific DNA binding