FOXK2 Gene Summary [Human]
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FOXK2 |
| Official Name | forkhead box K2 [Source:HGNC Symbol;Acc:HGNC:6036] |
| Ensembl ID | ENSG00000141568 |
| Bio databases IDs | |
| Aliases | forkhead box K2 |
| Synonyms | 1110054H05RIK, 5730434B08Rik, 6230415M23Rik, DKFZp434D1428, forkhead box K2, ILF, ILF-1, LOC102723820, LOC688330, nGTBP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- nucleic acid binding
- Forkhead associated domain
- cdk phosphorylation site
- protein binding
- magnesium ion binding
- sequence-specific DNA binding
- FORKHEAD
- Forkhead domain
- forkhead associated (FHA) domain superfamily
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FHA domain
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gout
- epithelial thyroid cancer
- ovarian cancer
- pneumonitis
- serous ovarian adenocarcinoma
- serous ovarian cancer
- breast carcinoma
- mucinous ovarian carcinoma
- mucinous ovarian cancer
role in cell
- phosphorylation in
- expression in
- apoptosis
- upregulation in
- migration
- activation in
- proliferation
- transcription in
- recruitment in
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of glucose metabolic process
- negative regulation of transcription, DNA-dependent
- cellular glucose homeostasis
- positive regulation of transcription, DNA-dependent
- negative regulation of autophagy
- response to starvation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity