FOXK1 Gene Summary [Human]
Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FOXK1 |
| Official Name | forkhead box K1 [Source:HGNC Symbol;Acc:HGNC:23480] |
| Ensembl ID | ENSG00000164916 |
| Bio databases IDs | |
| Aliases | forkhead box K1 |
| Synonyms | A630048H08Rik, forkhead box K1, FOXK1L, Gm10868, LOC221937, LOC679672, LOC686261, Mnf, RGD1309643 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- FH_FOX
- nucleic acid binding
- Forkhead associated domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- Forkhead domain
- forkhead associated (FHA) domain superfamily
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FHA domain
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypothyroidism
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
role in cell
- phosphorylation in
- expression in
- proliferation
- migration
- apoptosis
- autophagy by
- growth
- cell cycle progression
- survival
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- negative regulation of transcription from RNA polymerase II promoter
- regulation of glucose metabolic process
- negative regulation of transcription, DNA-dependent
- cellular glucose homeostasis
- positive regulation of transcription, DNA-dependent
- negative regulation of autophagy
- cell differentiation
- response to starvation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- 14-3-3 protein binding