PARP3
PARP3 Gene Summary
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PARP3 |
| Official Name | poly(ADP-ribose) polymerase family member 3 [Source:HGNC Symbol;Acc:HGNC:273] |
| Ensembl ID | ENSG00000041880 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 3, poly(ADP-ribose) synthetase-3, NAD+ ADP-ribosyltransferase 3, poly(ADP-ribose) polymerase 3 |
| Synonyms | A930002C11Rik,ADPRT-3,ADPRTL2,ADPRTL3,ARTD3,AW990611,IRT1,PADPRT-3,poly (ADP-ribose) polymerase family, member 3,poly(ADP-ribose) polymerase family member 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pentosyltransferase
- NAD ADP-ribosyltransferase
- Poly(ADP-ribose) polymerase, regulatory domain
- Poly(ADP-ribose) polymerase catalytic domain
- enzyme
- protein binding
- WGR domain
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the PARP3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PARP3
- RPA3
- H2BC21
- APP
- MTHFD2
- olaparib
- rucaparib
- H1-1
- H3C14
- APLF
disease
- cancer
- epithelial cancer
- metastatic castration resistant prostate adenocarcinoma
- epithelial ovarian cancer
- high-grade serous fallopian tube cancer
- endometrioid ovarian cancer
- fallopian tube cancer
- non-mucinous epithelial ovarian cancer
- serous fallopian tube cancer
- primary peritoneal serous cancer
regulated by
- lipopolysaccharide
- tetradecanoylphorbol acetate
- IFNB1
- TGFB1
- interferon stimulatory
- olaparib
- FANCE
- HMOX2
- rucaparib
- PRKAA1
regulates
- PARP1
- IFNB1
- NDRG1
- RUNX3
- NFASC
- DNA endogenous promoter
- PARVB
- DNA promoter
- NDRG2
- EPAS1
role in cell
- acetylation in
- expression in
- organization
- vincristine sensitivity
- dimethylation in
- vinorelbine sensitivity
- microtubule depolymerization in
- detyrosination in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic bridges
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PARP3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of isotype switching
- DNA ADP-ribosylation
- telomere maintenance
- protein poly-ADP-ribosylation
- protein auto-ADP-ribosylation
- positive regulation of double-strand break repair via nonhomologous end joining
- regulation of mitotic spindle organization
- double-strand break repair
- positive regulation of DNA ligation
CELLULAR COMPONENT
Where in the cell the gene product is active
- centrosome
- intercellular bridge
- site of double-strand break
- nuclear body
- cytoplasm
- centriole
- nucleolus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- catalytic activity
- NAD+ ADP-ribosyltransferase activity