TNC Gene Summary [Human]
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | TNC |
| Official Name | tenascin C [Source:HGNC Symbol;Acc:HGNC:5318] |
| Ensembl ID | ENSG00000041982 |
| Bio databases IDs | |
| Aliases | tenascin C, hexabrachion (tenascin) |
| Synonyms | 150-225, C130033P17Rik, cytotactin, DFNA56, GMEM, GP, HXB, JI, Ten, tenascin-C, TN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fibrinogen-like terminal knob
- extracellular matrix structural constituent
- protein binding
- Fibronectin type 3 domain
- syndecan binding
- fibronectin binding
- EGF-like domain
- EGF_CA
- fibronectin III-like domain
- FNIII-like repeat
- fibrinogen-like domain
- FN3
- integrin binding
- FReD
- Tenascin EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- gastric cancer
- breast cancer
- neoplasia
- metastasis
- glioblastoma cancer
- cancer
- glioma formation
- lung adenocarcinoma
- infiltrating ductal breast carcinoma
role in cell
- proliferation
- differentiation
- expression in
- apoptosis
- binding
- migration
- production in
- activation in
- quantity
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- endoplasmic reticulum lumen
- extracellular matrix
- membrane rafts
- perikaryon
- axons
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peripheral nervous system axon regeneration
- prostate gland epithelium morphogenesis
- negative regulation of cell adhesion
- positive regulation of cell proliferation
- response to wounding
- cell adhesion
- odontogenesis of dentin-containing tooth
- bud outgrowth involved in lung branching
- response to mechanical stimulus
- neuromuscular junction development
- response to ethanol
- cellular response to retinoic acid
- morphogenesis of an epithelium
- mesenchymal-epithelial cell signaling involved in prostate gland development
- regulation of cell growth
- positive regulation of gene expression
- osteoblast differentiation
- regulation of inflammatory response
- cellular response to prostaglandin D stimulus
- response to fibroblast growth factor stimulus
- regulation of cell adhesion
- regulation of cell migration
- cellular response to vitamin D
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- basement membrane
- interstitial matrix
- focal adhesion
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- syndecan binding
- integrin binding
- extracellular matrix structural constituent