TPR
TPR Gene Summary
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TPR |
| Official Name | translocated promoter region, nuclear basket protein [Source:HGNC Symbol;Acc:HGNC:12017] |
| Ensembl ID | ENSG00000047410 |
| Bio databases IDs | |
| Aliases | translocated promoter region, nuclear basket protein |
| Synonyms | 2610029M07Rik,FLJ13049,MRT79,translocated promoter region, nuclear basket protein |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, primarily archaeal type
- TPR/MLP1/MLP2-like protein
- exonuclease SbcC
- protein kinase binding
- nuclear pore localization signal
- mRNA binding
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- heat shock protein binding
- nuclear localization sequence
- Myosin tail
- helix-rich Mycoplasma protein
- leucine zipper domain
- chromatin binding
- protein binding
- YSPTSPS repeat
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- binding protein
- tubulin binding
- structural constituent of nuclear pore
- protein homodimerization
- Intermediate filament protein
- HOOK protein coiled-coil region
Pathways
Biological processes and signaling networks where the TPR gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CD274
- XPO1
- H3C1
- PPIA
- ADCY10
- PCLAF
- SUMO2
- DYRK1A
- PCCB
- YWHAB
disease
- neoplasia
- cancer
- preeclampsia
- epithelial cancer
- epithelial neoplasia
- atrial fibrillation
- organismal death
- breast cancer
- Hutchinson-Gilford progeria syndrome
- hyperplasia
regulated by
- dexamethasone
- UBE2I
- hydroxyurea
- beta-estradiol
- ESR1
- NUP98
- CCL2
- ITPR2
- PHA-665752
- LMNA
regulates
- ERK1/2
- AKT
- STAT5A/B
- DNA promoter
- DNA endogenous promoter
- IL1B
- TRA-AGC
- TRV-CAC1
- TRG-CCC1
- TRP-TGG
role in cell
- growth
- synthesis in
- phosphorylation in
- apoptosis
- expression in
- proliferation
- organization
- cell cycle progression
- transformation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- Cytoplasm
- perinuclear region
- nuclear foci
- nuclear pores
- nucleoplasm
- nucleoli
- outer nuclear membrane
- nuclear rim
- nuclear envelope
- nucleoplasmic baskets
- mitotic spindle
- kinetochores
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TPR gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- response to epidermal growth factor stimulus
- positive regulation of intracellular protein transport
- negative regulation of translational initiation
- negative regulation of RNA export from nucleus
- nuclear pore complex assembly
- negative regulation of transcription from RNA polymerase II promoter
- cell division
- nucleocytoplasmic transport
- nuclear pore organization
- cellular response to heat
- positive regulation of heterochromatin assembly
- mRNA export from nucleus in response to heat stress
- regulation of mRNA export from nucleus
- cellular response to interferon-alpha
- regulation of protein import into nucleus
- positive regulation of protein import into nucleus
- positive regulation of protein export from nucleus
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- regulation of protein localization
- nuclear matrix organization
- protein export from nucleus
- regulation of protein export from nucleus
- mRNA export from nucleus
- RNA import into nucleus
- regulation of protein stability
- RNA export from nucleus
- protein import into nucleus
- regulation of mitotic sister chromatid separation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nuclear envelope
- nuclear inclusion body
- nucleus
- nuclear membrane
- cytoplasmic dynein complex
- mitotic spindle
- cytoplasm
- nuclear periphery
- kinetochore
- nucleoplasm
- nuclear pore
MOLECULAR FUNCTION
What the gene product does at the molecular level
- tubulin binding
- heat shock protein binding
- protein homodimerization activity
- protein binding
- RNA binding
- protein anchor
- mRNA binding
- structural constituent of nuclear pore
- chromatin binding
- dynein complex binding
- mitogen-activated protein kinase binding