PCLAF Gene Summary [Human]
Enables chromatin binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PCLAF |
| Official Name | PCNA clamp associated factor [Source:HGNC Symbol;Acc:HGNC:28961] |
| Ensembl ID | ENSG00000166803 |
| Bio databases IDs | |
| Aliases | PCNA clamp associated factor, PCNA-associated factor |
| Synonyms | 2810417H13Rik, AA409629, KIAA0101, L5, mKIAA0101, Ns5apt9, NS5ATP9, OEATC, OEATC-1, p15PAF, p15/PAF, p15(PAF), PAF, PAF15, PCNA clamp associated factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCLAF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PCNA-associated factor histone like domain
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- schizophrenia
- psoriasis
- pancreatic cancer
- organismal death
- hypoplasia
- primary ovarian cancer
- HER2 negative hormone receptor negative breast cancer
role in cell
- quantity
- expression in
- apoptosis
- proliferation
- synthesis in
- accumulation in
- number
- growth
- development
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- nucleoplasm
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCLAF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome cycle
- DNA replication
- response to UV
- regulation of cell cycle
- response to DNA damage stimulus
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- binding, bridging