Tpr

Predicted to enable several functions, including dynein complex binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Involved in cellular response to interferon-alpha. Located in nuclear envelope; nuclear inclusion body; and nuclear periphery. Part of nuclear pore. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; olfactory epithelium; and vibrissa. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tpr gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpr gene, providing context for its role in the cell.