NOP16 Gene Summary [Human]
This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | NOP16 |
| Official Name | NOP16 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:26934] |
| Ensembl ID | ENSG00000048162 |
| Bio databases IDs | |
| Aliases | NOP16 nucleolar protein, hypothetical protein HSPC111, HBV pre-S2 trans-regulated protein 3 |
| Synonyms | D13Wsu177e, HSPC111, HSPC185, NOP16 nucleolar protein, RGD1305727 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOP16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosome biogenesis protein Nop16
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOP16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal large subunit biogenesis
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding