SRSF5 Gene Summary [Human]
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | SRSF5 |
| Official Name | serine and arginine rich splicing factor 5 [Source:HGNC Symbol;Acc:HGNC:10787] |
| Ensembl ID | ENSG00000100650 |
| Bio databases IDs | |
| Aliases | serine and arginine rich splicing factor 5, SR splicing factor 5 |
| Synonyms | Arginine/serine-rich 5, HRS, serine and arginine-rich splicing factor 5, SFRS5, SRP40 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRSF5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RS domain binding
- protein kinase binding
- RNA recognition motif
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- accumulation in
- apoptosis
- growth
- production in
- proliferation
- size
- alternative splicing in
- processing in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- vesicles
- cytosol
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRSF5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA splice site selection
- mRNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding