LMO3 Gene Summary [Human]
The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | LMO3 |
| Official Name | LIM domain only 3 [Source:HGNC Symbol;Acc:HGNC:6643] |
| Ensembl ID | ENSG00000048540 |
| Bio databases IDs | |
| Aliases | LIM domain only 3 |
| Synonyms | AI854781, BB106490, DAT1, LIM domain only 3, RBTN3, RBTNL2, RGD1561357, RHOM3, RHOM3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LMO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- preeclampsia
- renal cancer
- left-sided inattention
role in cell
- expression in
- growth
- differentiation
- transcription in
- colony formation
- recruitment in
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LMO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of glucocorticoid receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- metal ion binding