HES1 Gene Summary [Human]
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HES1 |
| Official Name | hes family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5192] |
| Ensembl ID | ENSG00000114315 |
| Bio databases IDs | |
| Aliases | hes family bHLH transcription factor 1 |
| Synonyms | bHLHb39, hes family bHLH transcription factor 1, HHL, HRY |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HES1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- helix 3-helix 4 domain
- transcription factor binding
- chromatin binding
- identical protein binding
- proline rich domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Hairy Orange
- chaperone binding
- helix-loop-helix domain
- loop domain
- Helix-loop-helix DNA-binding domain
- basic domain
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- histone deacetylase binding
- protein domain specific binding
- JUN kinase binding
- protein binding
- WRPW motif
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- binding protein
- double-stranded DNA binding
- protein homodimerization
- helix loop helix domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the HES1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- adenoma formation
- colorectal cancer
- exencephaly
- hypoplasia
- diabetic nephropathy
- organismal death
- non-small cell lung carcinoma
- non-small cell lung cancer
role in cell
- apoptosis
- phosphorylation in
- expression in
- proliferation
- migration
- quantity
- transcription in
- survival
- differentiation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intracellular space
- perinuclear region
- nucleoplasm
- nucleoli
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HES1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amacrine cell differentiation
- inner ear receptor stereocilium organization
- negative regulation of auditory receptor cell differentiation
- regulation of timing of neuron differentiation
- midbrain-hindbrain boundary morphogenesis
- anterior/posterior pattern specification
- positive regulation of astrocyte differentiation
- oculomotor nerve development
- positive regulation of DNA binding
- positive regulation of tyrosine phosphorylation of STAT protein
- trochlear nerve development
- Cajal-Retzius cell differentiation
- negative regulation of oligodendrocyte differentiation
- renal interstitial cell development
- midbrain development
- negative regulation of transcription, DNA-dependent
- negative regulation of neuron projection development
- BMP signaling pathway
- ascending aorta morphogenesis
- regulation of epithelial cell proliferation
- cell fate determination
- macromolecular complex assembly
- cochlea development
- adenohypophysis development
- common bile duct development
- artery morphogenesis
- smoothened signaling pathway
- regulation of JAK-STAT cascade
- response to alkaloid
- negative regulation of sequence-specific DNA binding transcription factor activity
- embryonic heart tube morphogenesis
- positive regulation of T cell proliferation
- response to organic cyclic compound
- ureteric bud morphogenesis
- positive regulation of mitotic cell cycle, embryonic
- regulation of secondary heart field cardioblast proliferation
- forebrain radial glial cell differentiation
- positive regulation of JAK-STAT cascade
- negative regulation of gene expression
- Notch signaling pathway
- labyrinthine layer blood vessel development
- positive regulation of gene expression
- glomerulus vasculature development
- regulation of neurogenesis
- telencephalon development
- positive regulation of cell proliferation
- nervous system development
- negative regulation of neuron differentiation
- outflow tract morphogenesis
- cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- S-shaped body morphogenesis
- neuronal stem cell maintenance
- positive regulation of Notch signaling pathway
- pancreatic A cell differentiation
- hindbrain morphogenesis
- thymus development
- negative regulation of transcription from RNA polymerase II promoter
- response to thyroid hormone stimulus
- cellular response to fatty acid
- negative regulation of forebrain neuron differentiation
- liver development
- negative regulation of stem cell differentiation
- somatic stem cell maintenance
- negative regulation of pro-B cell differentiation
- cellular response to tumor necrosis factor
- comma-shaped body morphogenesis
- cell migration
- lung development
- negative regulation of glial cell proliferation
- stomach neuroendocrine cell differentiation
- ventricular septum development
- regulation of protein complex assembly
- establishment of epithelial cell polarity
- cell maturation
- cell morphogenesis involved in neuron differentiation
- regulation of fat cell differentiation
- cardiac neural crest cell development involved in outflow tract morphogenesis
- negative regulation of calcium ion import
- metanephric nephron tubule morphogenesis
- vascular smooth muscle cell development
- ventricular septum morphogenesis
- negative regulation of stomach neuroendocrine cell differentiation
- regulation of transcription from RNA polymerase II promoter
- positive regulation of BMP signaling pathway
- auditory receptor cell differentiation
- T cell proliferation
- lateral inhibition
- cellular response to interleukin-1
- negative regulation of pancreatic A cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- histone deacetylase binding
- HLH domain binding
- sequence-specific DNA binding
- JUN kinase binding
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription corepressor binding
- DNA binding
- protein binding
- chaperone binding
- N-box binding
- E-box binding