RABL6 Gene Summary [Human]
This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | RABL6 |
| Official Name | RAB, member RAS oncogene family like 6 [Source:HGNC Symbol;Acc:HGNC:24703] |
| Ensembl ID | ENSG00000196642 |
| Bio databases IDs | |
| Aliases | RAB, member RAS oncogene family like 6, Rab-like protein 1, partner of ARF |
| Synonyms | B230208H17Rik, C9orf86, FLJ10101, PARF, pp8875, RAB, member RAS oncogene family-like 6, RBEL1, Rbel1a, Rbel1b, RGD1307615 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RABL6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian carcinoma
- epithelial ovarian cancer
- breast adenocarcinoma
- epithelial uterine cancer
- gastric carcinoma
- gastric epithelial cancer
- colon carcinoma
- colon epithelial cancer
- autosomal recessive nonsyndromic mental retardation
role in cell
- apoptosis
- proliferation
- phosphorylation in
- expression in
- growth
- cell death
- ubiquitination in
- G1 phase
- polyubiquitination in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- basal bodies
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RABL6 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding