HPF1 Gene Summary [Human]
Enables chromatin binding activity and histone binding activity. Involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Located in chromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HPF1 |
| Official Name | histone PARylation factor 1 [Source:HGNC Symbol;Acc:HGNC:26051] |
| Ensembl ID | ENSG00000056050 |
| Bio databases IDs | |
| Aliases | histone PARylation factor 1 |
| Synonyms | 2700029M09Rik, C230006B22Rik, C4orf27, FLJ20534, histone PARylation factor 1, RGD1311747 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HPF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding activity, bridging
- Uncharacterized conserved protein (DUF2228)
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
regulates
- NFkB (complex)
- PARP1
- niraparib
- olaparib
- AZD-2461
- A966492
role in cell
- proliferation
- migration
- activation in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HPF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of protein ADP-ribosylation
- response to DNA damage stimulus
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- poly-ADP-D-ribose binding
- protein binding
- histone binding
- chromatin binding