NPFFR2 Gene Summary [Human]
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | NPFFR2 |
| Official Name | neuropeptide FF receptor 2 [Source:HGNC Symbol;Acc:HGNC:4525] |
| Ensembl ID | ENSG00000056291 |
| Bio databases IDs | |
| Aliases | neuropeptide FF receptor 2, neuropeptide FF 2 |
| Synonyms | FF2, GPR74, HG31, HLWAR77, neuropeptide FF receptor 2, NPFF2, NPGPR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPFFR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the NPFFR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- COVID-19
- vitamin D deficiency
- central nervous system cancer
- obesity
- Huntington disease
- gallbladder neoplasm
- gallbladder neoplasia
- primary central nervous system lymphoma
- primary cancer
role in cell
- signaling in
- activation
- number
- binding
- dynamics in
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- actin cytoskeleton
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPFFR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- regulation of MAPK cascade
- G-protein coupled receptor signaling pathway
- detection of abiotic stimulus
- cellular response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide receptor activity
- opioid receptor binding
- peptide binding