CROCC Gene Summary [Human]
Predicted to enable kinesin binding activity and structural molecule activity. Involved in several processes, including centriole-centriole cohesion; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CROCC |
| Official Name | ciliary rootlet coiled-coil, rootletin [Source:HGNC Symbol;Acc:HGNC:21299] |
| Ensembl ID | ENSG00000058453 |
| Bio databases IDs | |
| Aliases | ciliary rootlet coiled-coil, rootletin, rootletin, ciliary rootlet protein |
| Synonyms | ciliary rootlet coiled-coil, rootletin, CROCC1, LOC230872, ROLT, ROOTLETIN, TAX1BP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CROCC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- globular domain
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- Myosin tail
- helix-rich Mycoplasma protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- kinesin binding
- Ciliary rootlet component, centrosome cohesion
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- structural constituent of cytoskeleton
- actin binding
- Coiled-coil domain-containing protein 158
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- leprosy
- rotator cuff tear
- seasonal allergic rhinitis
- infection by Influenza A virus subtype H3N2
role in cell
- cleavage
- cohesion
- assembly
- cycling
- degeneration
- homeostasis
- cleavage in
- ciliogenesis in
- maintenance
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- motile cilia
- actin cytoskeleton
- basal bodies
- centrosome
- centriole
- cytosol
- ciliary rootlet
- photoreceptor inner segments
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CROCC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
- centrosome cycle
- epithelial structure maintenance
- photoreceptor cell maintenance
- microtubule basal body organization
- centriole-centriole cohesion
- protein localization
- protein localization to organelle
- establishment of localization in cell
- positive regulation of flagellum assembly
- establishment of organelle localization
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- centrosome
- extracellular vesicular exosome
- centriole
- actin cytoskeleton
- cytosol
- photoreceptor inner segment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- kinesin binding
- structural molecule activity
- structural constituent of cytoskeleton