PTPRU Gene Summary [Human]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | PTPRU |
| Official Name | protein tyrosine phosphatase receptor type U [Source:HGNC Symbol;Acc:HGNC:9683] |
| Ensembl ID | ENSG00000060656 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase receptor type U, pi R-PTP-Psi |
| Synonyms | FMI, Ftp-1, hPTP-J, PCP-2, protein tyrosine phosphatase receptor type U, protein tyrosine phosphatase, receptor type, U, PTP, Ptpf, PTP-J, PTP-lambda, PTP-PI, PTPPSI, PTPRL, PTP-RO, PTPU2, PTP-λ, RPTPlambda, RPTP-PI, R-PTP-PSI, R-PTP-U |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTPRU often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- beta-catenin binding
- immunoglobulin domain
- Protein tyrosine phosphatase, catalytic domain
- Purple acid Phosphatase, N-terminal domain
- Fibronectin type 3 domain
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- cytoplasmic domain
- FN3
- Immunoglobulin like
- phosphatase
- MAM domain, meprin/A5/mu
Pathways
Biological processes and signaling networks where the PTPRU gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early onset hypertension
- lung adenocarcinoma
- lung adenocarcinoma formation
- Tourette syndrome
- infection by HIV-1
role in cell
- migration
- proliferation
- replication in
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTPRU gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- negative regulation of cell proliferation
- protein dephosphorylation
- transmembrane receptor protein tyrosine phosphatase signaling pathway
- cell adhesion
- negative regulation of canonical Wnt receptor signaling pathway
- response to glucocorticoid stimulus
- cell differentiation
- organ regeneration
- homotypic cell-cell adhesion
- positive regulation of cell-cell adhesion mediated by cadherin
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity
- beta-catenin binding