MIR17HG Gene Summary [Human]
This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]
Details
| Type | Retained Intron |
| Official Symbol | MIR17HG |
| Official Name | miR-17-92a-1 cluster host gene [Source:HGNC Symbol;Acc:HGNC:23564] |
| Ensembl ID | ENSG00000215417 |
| Bio databases IDs | |
| Aliases | miR-17-92a-1 cluster host gene, non-protein coding RNA 48, long intergenic non-protein coding RNA 48 |
| Synonyms | 5033413D16RIK, C13orf25, Fli-3, FLJ14178, host gene 1 (non-protein coding), LINC00048, MGC126270, microRNA-17~92 cluster, MIHG1, miR-17-92, miR-17-92a-1 cluster host gene, miR-17~92 cluster, MIR-17-92 cluster, miR-17~92 cluster concept, miR-17-92 cluster host, MIR-17-92 host, MIR-17-92 host gene, miR-17-92 microrna cluster, MIR-17-92 microrna host, MIR-17-92 microrna host gene, Mir17 host gene (non-protein coding), MIRH1, MIRHG1, NCRNA00048 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma
- cancer
- adenoma formation
- epithelial cancer
- experimental autoimmune encephalomyelitis
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- expression in
- migration
- growth
- proliferation
- cell viability
- cell death
- apoptosis
- activation
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR17HG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- positive regulation of cardiac muscle cell proliferation
- gene silencing by miRNA
- regulation of B cell differentiation
- outflow tract morphogenesis
- lung growth
- ventricular septum morphogenesis
- B cell homeostasis
- cardiac right ventricle morphogenesis
- positive regulation of muscle hyperplasia
- negative regulation of B cell apoptotic process
- regulation of B cell activation
Cellular Component
Where in the cell the gene product is active
- RNA-induced silencing complex