SEC61A2 Gene Summary [Human]
The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | SEC61A2 |
| Official Name | SEC61 translocon subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:17702] |
| Ensembl ID | ENSG00000065665 |
| Bio databases IDs | |
| Aliases | SEC61 translocon subunit alpha 2 |
| Synonyms | FLJ10578, SEC61 translocon subunit alpha 2, SEC61 translocon subunit α 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEC61A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plug domain of Sec61p
- ribosome binding
- SecY
- protein binding
- transporter
- preprotein translocase, SecY subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEC61A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, translocation
- posttranslational protein targeting to membrane, translocation
Cellular Component
Where in the cell the gene product is active
- Sec61 translocon complex
Molecular Function
What the gene product does at the molecular level
- protein transmembrane transporter activity
- ribosome binding
- signal sequence binding