TRAPPC1 Gene Summary [Human]
This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | TRAPPC1 |
| Official Name | trafficking protein particle complex 1 [Source:HGNC Symbol;Acc:HGNC:19894] |
| Ensembl ID | ENSG00000170043 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 1, trafficking protein particle complex subunit 1 |
| Synonyms | BET5, D11Ertd172e, MUM2, trafficking protein particle complex 1, trafficking protein particle complex subunit 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAPPC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sedlin, N-terminal conserved region
- protein binding
- Longin-like domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- expression in
- phosphorylation in
- differentiation
- apoptosis
- cellular infiltration by
- quantity
- number
- ferroptosis
- maturation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- Golgi Apparatus
- cytosol
- cis Golgi networks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAPPC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle coating
- ER to Golgi vesicle-mediated transport
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- cytoplasm
- cytosol
- endoplasmic reticulum
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein binding